Exploring AAVs

Join host Abbie Breton and special guest Yuliya McAnany on Chromatography Experts as we explore AAV purification, cell & gene therapy advancements, and a new method from Tosoh that’s reshaping how researchers separate full and empty AAV capsids.

We break down the science behind our recent paper, ‘Preparative choline-based anion-exchange chromatography for enrichment of full adeno-associated virus capsids’ and reveal the results, up to 90% full capsids with 75% recovery.

You’ll also hear insights on scalability, method adaptation for other viral vectors, and expert advice for improving purification workflows. If you work with AAVs, this is an episode you don’t want to miss.

The paper can be found here: https://www.sciencedirect.com/science/article/pii/S0021967325006636